These are the research projects that BDRF have funded.
If you’re thinking about starting your own project and would like to apply for a bursary, please see our how to apply page.
All of our work is reliant on fundraising – we get no financial support from the government. If you would like to support our work we would be delighted if you would consider making a donation here.
Comparison of the diagnostic accuracy of 3D volume acquisition MRI with CT in staging colonic cancer
Before treatment, patients with newly diagnosed cancer undergo ‘staging’ to assess how advanced the cancer is. This determines what treatment is best, and is becoming increasingly important as more treatment options become available.
Is there greater tumour response as determined by tumour cell density at 6 weeks or 12 weeks following completion of chemo/radiotherapy?
About 15,000 people are diagnosed with rectal cancer every year in the UK. Currently 35-45% of such patients receive radiotherapy before their operation to reduce the chance of local and distant recurrence.
An enterocutaneous fistula is a connection between the bowel and the skin. Almost all form after surgery and lead to a number of serious and debilitating complications. These include the need for patients to have a temporary or permanent feeding line placed into a neck vein through which formulae feed is passed on a daily basis.
Pyoderma gangrenosum (PG) is a distressing condition in which some patients with inflammatory bowel disease develop painful skin and stomal ulcers. All current treatment for PG is unsatisfactory and there is virtually no scientific evidence for benefit from any of the commonly used drugs.
This research aims to apply a new technique using light and computers, during colonoscopy, which can be used to instantly diagnose pre-cancer and cancer.
A novel approach to enhancing the effectiveness of chemotherapy: a biomarker driven study combining curcumin with FOLFOX in metastatic (spreading) colorectal cancer
The aim of the project is to determine whether combining curcumin (the main constituent of the spice turmeric) with FOLFOX (a type of chemotherapy) enhances treatment efficacy and/or decreases toxicity compared with FOLFOX alone.
The role of new scanning methods in improving surgical technique and outcomes in more extensive pelvic surgery for recurrent and locally advanced primary rectal cancer
In the UK around 14,000 people are diagnosed with rectal cancer each year. Despite recent advances up to 15% of surgically treated rectal cancers develop local recurrence of the cancer, and in a proportion of these patients further surgery provides the best hope of cure.
This project aims to improve the management of recurrent bowel cancer through the analysis of different body fluids using a new technique called ‘Metabonomics’.
Characterisation of crypt cell changes as signifiers of risk of colorectal tumours (benign and malignant)
Cells in the body and, in particular, in the bowel are constantly being replaced. Replacement cells are formed in microscopic areas of the colon called crypts. Cancer and its precursor, bowel polyps, are formed when there is unregulated and overproduction of colonic cells.
A Prospective Randomised Placebo Controlled Study of Percutaneous and Trans-cutaneous Tibial Nerve Stimulation in Idiopathic Faecal Incontinence
There is some evidence that electrical stimulation of a nerve in the foot (the posterior tibial nerve) has beneficial effects in reducing the number of episodes of involuntary loss of stool (faecal incontinence) in patients who suffer from this condition.