These are the research projects that BDRF have funded.
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A trial of a new device (which can be worn at home) to see if it will reduce the severity of symptoms of people suffering from faecal incontinence
Faecal incontinence (FI) is a common and distressing condition. While milder symptoms can be managed by one of several drug and behavioural strategies, many patients still need surgery, often with poor results.
The development of a technique detecting an anastomotic leak after bowel surgery to reduce complications and death rates
In colorectal surgery an anastomosis is the medical term for joining together the healthy sections of the colon or rectum after a cancerous or otherwise diseased portion has been surgically removed.
Do the levels in the body of two hormones (Vitamin D and parathyroid hormone, or PTH) increase the risk of developing bowel cancer?
Colorectal cancer is a common disease: every year in the UK there are over 39,000 new patients and more than 16,000 deaths. A number of factors influencing the development and progression of colorectal cancer have been recognised, but few of these factors are easily modifiable in a way that allows prevention or treatment of the disease.
Does lymphatic mapping identify the “sentinel” lymph node near an early stage bowel cancer, thus enabling patients with no cancer in their lymph nodes to undergo less radical surgery than currently, reducing risk to the patient and shortening their stay in hospital?
Currently, the same operation – removal by surgery of the primary cancerous site and draining of the related lymph nodes – is proposed for all patients with colorectal cancer.
Bowel surgery is undertaken on over 60,000 patients a year in the UK. It can result in a prolonged post-operative recovery period, including several weeks in hospital, which can hinder recovery. Persistent nausea and vomiting is an important cause of prolonged hospital stay following bowel surgery as the bowel is slow to start working after the operation.
The effect of sacral neuromodulation on cortical processing of anal canal inputs in patients with faecal incontinence
The nerves which supply the pelvic floor can be injured during childbirth, and this can subsequently cause the distressing condition of faecal incontinence. Recently, electrical nerve root stimulation (sacral neuromodulation or SNM) has been applied successfully to such patients.
The expression of colorectal cancer cell adhesion molecules and their affect on anti-inflammatory immune cell function
Colorectal cancer (CRC) is the second most common cause of cancer death in the UK and accounted for 16,007 deaths in 2007. Laboratory analysis of CRC shows that some tumours have a paucity of immune cells while others have an abundance of anti-inflammatory immune cells (AIC)
Over 100 new cases of bowel cancer are diagnosed every day in the UK. Unfortunately, more than half these patients have advanced disease at the time of detection. Early detection of bowel cancer by screening reduces cancer- related mortality.
Rectal prolapse occurs when the rectum (the terminal part of the large intestine) descends to lie outside the anus. It is a common problem, affecting up to 10% of the population.
Sentinel lymph node detection in anal cancer: A feasibility study of indocyanine green fluorescence and conventional blue dye/radiocolloid mapping
Anal cancer is a painful, debilitating and potentially fatal disease. About 850 new cases are diagnosed in the UK each year. The treatment of choice is chemotherapy and radiotherapy; surgery is reserved for when the disease recurs or does not fully respond.