These are the research projects that BDRF have funded.
If you’re thinking about starting your own project and would like to apply for a bursary, please see our how to apply page.
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Making radiotherapy for rectal cancer more effective by identifying which drugs should be used for individual patients
When diagnosed, over 5000 patients every year in the UK have rectal cancer that cannot be surgically removed unless it can first be shrunk by chemotherapy and radiotherapy. Doctors UK-wide currently treat all these patients with exactly the same chemotherapy and radiotherapy over 5 weeks.
Colorectal cancer is the second highest cause of cancer deaths in the UK. There is a protein called heat shock protein-27 (HSP27) which protects stressed cells from dying.
Improving treatment of bowel cancer by studying the use of a specific protein during colonoscopy in order to identify those abnormal and cancer cells missed by current methods
Early forms of bowel cancer can be treated and the cancer removed, preventing the disease from returning. Colonoscopy is examination of the interior of the entire colon and rectum using a flexible illuminated camera-instrument introduced through the anus; it is important in the diagnosis and treatment of bowel cancer.
Investigation to discover if the presence of a genetic defect in a particular protein indicates that bowel cancer cells will not spread around the body, thus removing the need for chemotherapy
Bowel cancer is the second most common cause of cancer death in the UK. Treatment usually involves surgery to remove the main tumour and some patients require chemotherapy to reduce the risk of cancer cells spreading around the body. Up to a quarter of patients will have spread of cancer in the following 5 years, but not all bowel cancers act in the same way.
Identification of biological markers that will accurately predict whether or not patients with colorectal cancer need chemotherapy after their surgery
Patients who have colorectal cancer are often cured by surgery alone. However some patients will require chemotherapy after surgery. It is currently not always possible to identify which patients will benefit from having chemotherapy.
Investigation of blood flow in large and small blood vessels with the aim of improving outcomes for patients undergoing colorectal and other major surgery
Optimisation of blood supply to small vessels of vital organs during an operation may reduce complications associated with surgery. By using ultrasound placed in the gullet the amount of blood received during operations can be improved.
Can we develop more sensitive instruments for use in laparoscopic (keyhole) surgery which will make operations safer and reduce the complications associated with laparoscopic surgery?
Laparoscopic surgery is increasingly used in the management of colorectal disease, and involves the use of long instruments inserted into the abdomen through small incisions.