Preop chemoradiation in locally advanced rectal cancer is associated with less local recurrence
This Cochrane review assesses the efficacy of pre-operative chemoradiation (CRT) with radiotherapy (RT) alone before surgery in the treatment of locally advanced, non-metastatic rectal surgery. 6 randomised controlled trials eligible for inclusion. A reduction in local recurrence was seen in the CRT group in comparison to the RT group. The 30 day mortality was the same for both groups as was sphincter preservation measured by stoma rate. An increase in acute grade 3/4 treatment related toxicity was seen in the CRT group, but late toxicity events were similar.
Synopsis provided by the schoolofsurgery.org
BDRF is pleased to make use of this link and hopes the information proves useful. We recognise that this is not the only School of Surgery and would welcome further links to any other appropriate sites.